NEWLY ESTABLISHED MORI LAB

The lung is one of the most complex organs to regenerate.  Current bioengineering technologies utilizing three-dimensional printers and decellularization-recellularization have had limited success. Recently, we established an experimental basis of lung generation in vivo (Mori et al., Nature Medicine, 2019). 

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We will further focus on advancing our lung generation technology for realizing in vivo disease-modeling and autologous lung transplantation in vivo.

MORI ET AL., NATURE MEDICINE, 2019, IN PRESS

November 7th, 2019

Millions of people worldwide suffering from incurable end-stage lung disease die due to inadequate treatment options and limited availability of donor organs for transplantation. Current bioengineering strategies to regenerate the lung have not been able to replicate its extraordinary complexity, which contains billions of cells indispensable for life-sustaining gas-exchange. Here we report the first experimental evidence of successful regeneration of a functional lung in vivo using a conditional blastocyst complementation (CBC) approach, coupled with a newly-established pluripotent stem cell culture condition. These results pave the way for the development of novel strategies for lung generation and disease-modeling in large animals and cell-based interventions in human conditions.