Mori Lab: Laboratory for 

Respiratory Health and Respiratory Organ Generation

Exploring the Future of Respiratory Health and Respiratory Organ Generation Technology.

Our research focus is on understanding the fundamental cellular- and molecular mechanisms behind intra- or interspecies respiratory biology. We are seeking an innovative treatment for maintaining our respiratory health. The ultimate goal for our state-of-the-art lung generation technology is to transform care for patients with refractory lung diseases.

NEWS & RESOURCES

Stay in the Know

   As a leading Lung Bioengineering Laboratory in the New York area, we are happy to engage with the community and keep them informed about our innovative work and developments. We are fighting against COVID-19.

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NEWLY ESTABLISHED MORI LAB

The lung is one of the most complex organs to regenerate.  Current bioengineering technologies utilizing three-dimensional printers and decellularization-recellularization have had limited success. Recently, we established an experimental basis of lung generation in vivo (Mori et al., Nature Medicine, 2019). 

We will further focus on advancing our lung generation technology for realizing in vivo disease-modeling and autologous lung transplantation in vivo.

MORI ET AL., NATURE MEDICINE, 2019, IN PRESS

November 7th, 2019

Millions of people worldwide suffering from incurable end-stage lung disease die due to inadequate treatment options and limited availability of donor organs for transplantation. Current bioengineering strategies to regenerate the lung have not been able to replicate its extraordinary complexity, which contains billions of cells indispensable for life-sustaining gas-exchange. Here we report the first experimental evidence of successful regeneration of a functional lung in vivo using a conditional blastocyst complementation (CBC) approach, coupled with a newly-established pluripotent stem cell culture condition. These results pave the way for the development of novel strategies for lung generation and disease-modeling in large animals and cell-based interventions in human conditions.

LAB MEMBERS

Our people make the Mori Lab such a unique and fulfilling place to work. We’re proud of the diversity of our staff, with each member contributing their unique skills to the projects we’re working on. Together, we’ve planned and executed some of the most innovative and cutting edge experiments. Find out more about our team members below.

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MOONEY
(DR. MUNEMASA MORI)

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Get in touch with our lab members today.

Lab memory and events

RESEARCH

Unlocking the Mysteries of respiratory organ generation

We are interested in studying the complex organogenesis program in mammalian embryogenesis.

Our long-term goal is to identify and characterize the molecular and cellular mechanisms underlying human lung generation in vivo to realizing autologous lung transplantation and disease-modeling in vivo for patients suffering from refractory lung diseases.

See below our unique approaches for analyzing respiratory organ generation.

Building a novel paradigm for complex organ formation by genome manipulation

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Discover cellular and molecular functions and control them in  regenerated tissues 

Unveiling hidden cellular and molecular mechanisms governing intercellular function by real-time time-lapse imaging and genome-wide single-cell level analyses

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Exploring molecular features of pluripotent stem cells and

the host organogenesis program, applicable for respiratory organ generation

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Want to learn more about our research projects?

Visualizing invisible cellular or intracellular microorganisms in  regenerated organs by

3D-SIM IMAGING

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CONTACT US

Mori lab, Columbia Center for Human Development: 212-305-1731

The Fruits of Our Labor

Expect the unexpected in research. Each project the Mori Lab works on comes with both unforeseeable challenges and opportunities. Many of the papers we’ve published were born out of a passion for science, Experiments are performed on the fly or purely for curiosity's sake. Check out the research projects and list of our lab’s publications below, and you are welcome to contact us for more information.