Mori Lab: Laboratory for 

Respiratory Health and Respiratory Organ Generation

Exploring the Future of Respiratory Health and Respiratory Organ Generation Technology.

Our research focus is on understanding the fundamental cellular- and molecular mechanisms behind intra- or interspecies respiratory biology. We are seeking an innovative treatment for maintaining our respiratory health. The ultimate goal for our state-of-the-art lung generation technology is to transform care for patients with refractory lung diseases.

NEWLY ESTABLISHED MORI LAB

October 21, 2019

The lung is one of the most complex organs to regenerate.  Current bioengineering technologies utilizing three-dimensional printers and decellularization-recellularization have had limited success. Recently, we established an experimental basis of lung generation in vivo (Mori et al., Nature Medicine, 2019). 

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We will further focus on advancing our lung generation technology for realizing in vivo disease-modeling and autologous lung transplantation in vivo.

MORI ET AL., NATURE MEDICINE, 2019, IN PRESS

November 7th, 2019

Millions of people worldwide suffering from incurable end-stage lung disease die due to inadequate treatment options and limited availability of donor organs for transplantation. Current bioengineering strategies to regenerate the lung have not been able to replicate its extraordinary complexity, which contains billions of cells indispensable for life-sustaining gas-exchange. Here we report the first experimental evidence of successful regeneration of a functional lung in vivo using a conditional blastocyst complementation (CBC) approach, coupled with a newly-established pluripotent stem cell culture condition. These results pave the way for the development of novel strategies for lung generation and disease-modeling in large animals and cell-based interventions in human conditions.

LAB MEMBERS

Our people make the Mori Lab such a unique and fulfilling place to work. We’re proud of the diversity of our staff, with each member contributing their unique skills to the projects we’re working on. Together, we’ve planned and executed some of the most innovative and cutting edge experiments. Find out more about our team members below.

MOONEY

(DR. MUNEMASA MORI)

Principal Investigator,

Assistant Professor of Medicine,

Columbia Center for Human Development (CCHD),

Pulmonary Allergy & Critical Care Medicine, Department of Medicine,

Columbia University Irving Medical Center

Humor in our life, science, and innovation. These are just a few things Mooney deserves in his lab. He has developed an experimental basis for functional lung generation in mice. He is advancing his technology towards human lung generation and in vivo disease-modeling with his lab mates.

ROSE

(ROSE GORDON-SCHNEIDER)

Lab tech

Rose came from New Zealand and join Dr. Mori's lab. Her passion for science and dedication to helping lab mates are essential for the realization of our difficult mission. Professionalism to a tee and her organization into Mori Lab, 

ANRI

(DR. ANRI SAWADA)

Post-Doc

Anri is a new postdoc In Dr. Mori's lab and has a mind teeming with innovative ideas and outside-the-box solutions. He is a medical doctor (MD) and his specialty is in nephrology and pathology. He is going to study the regulatory mechanism controlling lung generation in our organ generation system.

The Fruits of Our Labor

Expect the unexpected in research. Each project the Mori Lab works on comes with both unforeseeable challenges and opportunities. Many of the papers we’ve published were born out of a passion for science, Experiments are performed on the fly or purely for curiosity's sake. Check out the research projects and list of our lab’s publications below, and you are welcome to contact us for more information.